Mohana Choorna

Europa Ayurveda Centrum (EAC) took the initiative to start a project to investigate the possibility of Ayurveda in the Netherlands. However, this very well established way of prevention and treatment of illness in India, is not yet fully accepted in the Netherlands. Therefore, EAC was interested to acquire scientific evidence, accepted by the Western world, regarding an Ayurvedic herbal product ‘Mohana Choorna’ used for the treatment of Diabetes Mellitus type 2 (DM2).

Mohana Choorna

Mohana Choorna consists of 20 herbs cultivated at the EAC in the Netherlands. EAC investigated the effect of Mohana Choorna (MC) on DM2 patients in a randomised, double-blind, placebo-controlled clinical trial. Diabetes mellitus, often simply referred to as diabetes—is a multi-system dysfunction in which a person has high blood sugar. Either because the body does not produce enough insulin or because cells do not respond to the produced insulin. Also, there are several factors that are not obvious from biological considerations alone. Therefore, the search for a single drug target to the reversal of all or majority of the aspects of the disease might not give the solution. Because biological systems are too complex to be fully understood through conventional and isolated experimentations, as they are not always linear.

Holistic versus One Target

The Ayurvedic preparation MC contains a variety of herbal ingredients that incorporate synergistic, potentiation, agonistic, antagonistic pharmacological agents, and hence act on a variety of targets by various modes and mechanisms. Therefore, the therapeutic approach of MC is more holistic than regularly used Western medicines for DM2. For that reason, EAC is especially interested in changes in the system biology after the use of MC resulting in lowering blood sugar levels (glycosylated haemoglobin), blood lipid levels (triglyceride, total cholesterol, Low-Density Lipoprotein and High-Density Lipoprotein) in DM2 patients.

Panchagavyam

Furthermore, EAC examined which plant compounds, including already proven health-promoting metabolites, are present in the 20 herbs comprising MC, which are cultivated using a traditional Indian method of natural fertiliser (Panchagavyam). The presence of these plant metabolites in the preparation of the MC herbal product, and in the blood and/or urine of the treated patients during the intervention study will be analysed. Using holistic unbiased metabolomics techniques for the analysis of the herbs and the MC herbal preparation complies to the system biology approach for the herbal medicine and it’s acted of function.

vergadering wur

Consortium

For these studies, a research collaboration between EAC, WUR Human Nutrition (HN) and WUR Plant Research International (PRI), Canisius Wilhelmina Hospital and EuroProxima took place. EAC supplied the plant materials and WUR HN and Canisius Wilhelmina did the clinical trial. WUR PRI did the compound analyses and EuroProxima the research into the mycotoxins in herbs and earth.